Pesquisa | BVS IEC

1.

Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease.

Hayase, Eiko; Hayase, Tomo; Jamal, Mohamed A; Miyama, Takahiko; Chang, Chia-Chi; Ortega, Miriam R; Ahmed, Saira S; Karmouch, Jennifer L; Sanchez, Christopher A; Brown, Alexandria N; El-Himri, Rawan K; Flores, Ivonne I; McDaniel, Lauren K; Pham, Dung; Halsey, Taylor; Frenk, Annette C; Chapa, Valerie A; Heckel, Brooke E; Jin, Yimei; Tsai, Wen-Bin; Prasad, Rishika; Tan, Lin; Veillon, Lucas; Ajami, Nadim J; Wargo, Jennifer A; Galloway-Peña, Jessica; Shelburne, Samuel; Chemaly, Roy F; Davey, Lauren; Glowacki, Robert W P; Liu, Chen; Rondon, Gabriela; Alousi, Amin M; Molldrem, Jeffrey J; Champlin, Richard E; Shpall, Elizabeth J; Valdivia, Raphael H; Martens, Eric C; Lorenzi, Philip L; Jenq, Robert R.

Cell ; 185(20): 3705-3719.e14, 2022 09 29.

Artigo em Inglês | MEDLINE | ID: mdl-36179667

2.

Structure of a B₁₂-dependent radical SAM enzyme in carbapenem biosynthesis.

Knox, Hayley L; Sinner, Erica K; Townsend, Craig A; Boal, Amie K; Booker, Squire J.

Nature ; 602(7896): 343-348, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-35110734

3.

Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome.

Morgan, Christopher E; Kang, Yoon-Suk; Green, Alex B; Smith, Kenneth P; Dowgiallo, Matthew G; Miller, Brandon C; Chiaraviglio, Lucius; Truelson, Katherine A; Zulauf, Katelyn E; Rodriguez, Shade; Kang, Anthony D; Manetsch, Roman; Yu, Edward W; Kirby, James E.

PLoS Biol ; 21(5): e3002091, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-37192172

4.

A conserved zinc-binding site in Acinetobacter baumannii PBP2 required for elongasome-directed bacterial cell shape.

Micelli, Carmina; Dai, Yunfei; Raustad, Nicole; Isberg, Ralph R; Dowson, Christopher G; Lloyd, Adrian J; Geisinger, Edward; Crow, Allister; Roper, David I.

Proc Natl Acad Sci U S A ; 120(8): e2215237120, 2023 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-36787358

5.

High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo.

Ragunathan, Priya; Sae-Lao, Patcharaporn; Hamela, Claire; Alcaraz, Matthéo; Krah, Alexander; Poh, Wee Han; Ern Pee, Carmen Jia; Hou Lim, Albert Yick; Rice, Scott A; Pethe, Kevin; Bond, Peter J; Dick, Thomas; Kremer, Laurent; Bates, Roderick W; Grüber, Gerhard.

J Biol Chem ; 300(2): 105618, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38176652

6.

Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection.

Eckburg, Paul B; Muir, Lori; Critchley, Ian A; Walpole, Susannah; Kwak, Hanna; Phelan, Anne-Marie; Moore, Gary; Jain, Akash; Keutzer, Tim; Dane, Aaron; Melnick, David; Talley, Angela K.

N Engl J Med ; 386(14): 1327-1338, 2022 04 07.

Artigo em Inglês | MEDLINE | ID: mdl-35388666

7.

Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005-2023.

Li, Yan; Sun, Xinran; Dong, Ning; Wang, Zhiqiang; Li, Ruichao.

Drug Resist Updat ; 72: 101031, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38071860

8.

ThnL, a B12-dependent radical S-adenosylmethionine enzyme, catalyzes thioether bond formation in carbapenem biosynthesis.

Sinner, Erica K; Li, Rongfeng; Marous, Daniel R; Townsend, Craig A.

Proc Natl Acad Sci U S A ; 119(34): e2206494119, 2022 08 23.

Artigo em Inglês | MEDLINE | ID: mdl-35969793

9.

Recurrent emergence of Klebsiella pneumoniae carbapenem resistance mediated by an inhibitory ompK36 mRNA secondary structure.

Wong, Joshua L C; David, Sophia; Sanchez-Garrido, Julia; Woo, Jia Z; Low, Wen Wen; Morecchiato, Fabio; Giani, Tommaso; Rossolini, Gian Maria; Beis, Konstantinos; Brett, Stephen J; Clements, Abigail; Aanensen, David M; Rouskin, Silvi; Frankel, Gad.

Proc Natl Acad Sci U S A ; 119(38): e2203593119, 2022 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-36095213

10.

Interactions of hydrolyzed ß-lactams with the L1 metallo-ß-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.

Hinchliffe, Philip; Calvopiña, Karina; Rabe, Patrick; Mojica, Maria F; Schofield, Christopher J; Dmitrienko, Gary I; Bonomo, Robert A; Vila, Alejandro J; Spencer, James.

J Biol Chem ; 299(5): 104606, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36924941

11.

Individualized Antibiotic Plans as a Quality Improvement Initiative to Reduce Carbapenem Use for Hematopoietic Cell Transplant Patients at a Freestanding Pediatric Hospital.

Brothers, Adam W; Pak, Daniel J; Poole, Nicole M; Kronman, Matthew P; Bettinger, Brendan; Wilkes, Jennifer J; Carpenter, Paul A; Englund, Janet A; Weissman, Scott J.

Clin Infect Dis ; 78(1): 15-23, 2024 Jan 25.

Artigo em Inglês | MEDLINE | ID: mdl-37647637

12.

Identifying Effective Durations of Antibiotic Therapy for the Treatment of Carbapenem-resistant Enterobacterales Bloodstream Infections: A Multicenter Observational Study.

Soto, Caitlin L; Hsu, Alice J; Lee, Jae Hyoung; Dzintars, Kathryn; Choudhury, Rebecca; Jenkins, Timothy C; McCreary, Erin K; Quartuccio, Katelyn S; Stohs, Erica J; Zimmerman, Matty; Tamma, Pranita D.

Clin Infect Dis ; 78(1): 27-30, 2024 Jan 25.

Artigo em Inglês | MEDLINE | ID: mdl-37584360

13.

Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions.

Wang, Minggui; Ge, Lizhao; Chen, Liang; Komarow, Lauren; Hanson, Blake; Reyes, Jinnethe; Cober, Eric; Alenazi, Thamer; Zong, Zhiyong; Xie, Qing; Liu, Zhengyin; Li, Lanjuan; Yu, Yunsong; Gao, Hainv; Kanj, Souha S; Figueroa, Jairo; Herc, Erica; Cordova, Ezequiel; Weston, Gregory; Ananth Tambyah, Paul; Garcia-Diaz, Julia; Kaye, Keith S; Dhar, Sorabh; Munita, Jose M; Salata, Robert A; Vilchez, Samuel; Stryjewski, Martin E; Villegas Botero, Maria Virginia; Iovleva, Alina; Evans, Scott R; Baum, Keri; Hill, Carol; Kreiswirth, Barry N; Patel, Robin; Paterson, David L; Arias, Cesar A; Bonomo, Robert A; Chambers, Henry F; Fowler, Vance G; Satlin, Michael J; van Duin, David; Doi, Yohei.

Clin Infect Dis ; 78(2): 248-258, 2024 Feb 17.

Artigo em Inglês | MEDLINE | ID: mdl-37738153

14.

A preliminary exploration on the mechanism of the carbapenem-resistance transformation of Serratia marcescens in vivo.

Xu, Qian; Zheng, Beiwen; Li, Kaixuan; Shen, Ping; Xiao, Yonghong.

BMC Genomics ; 25(1): 2, 2024 Jan 02.

Artigo em Inglês | MEDLINE | ID: mdl-38166565

15.

Respiratory carriage of hypervirulent Klebsiella pneumoniae by indigenous populations of Malaysia.

Das, Souradeep; Pandey, Anish K; Morris, Denise E; Anderson, Rebecca; Lim, Victor; Wie, Chong Chun; Yap, Ivan Kok Seng; Alattraqchi, Ahmed Ghazi; Simin, Hafis; Abdullah, Ramle; Yeo, Chew Chieng; Clarke, Stuart C; Cleary, David W.

BMC Genomics ; 25(1): 381, 2024 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-38632538

16.

Exploring the resistome, virulome, and mobilome of multidrug-resistant Klebsiella pneumoniae isolates: deciphering the molecular basis of carbapenem resistance.

Rahmat Ullah, Sidra; Irum, Sidra; Mahnoor, Iqra; Ismatullah, Humaira; Mumtaz, Mariam; Andleeb, Saadia; Rahman, Abdur; Jamal, Muhsin.

BMC Genomics ; 25(1): 408, 2024 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-38664636

17.

Simulated drug disposition in critically ill patients to evaluate effective PK/PD targets for combating Pseudomonas aeruginosa resistance to meropenem.

Zhang, Xiaonan; Wang, Yan; Li, Sanwang; Xie, Feifan; Yi, Hanxi.

Antimicrob Agents Chemother ; 68(3): e0154123, 2024 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-38319075

18.

Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan.

Sarangi, Jayathilake; Ido, Ayaka; Ito, Masaya; Iinuma, Chihiro; Doyama, Yo; Jin, Wanchun; Wachino, Jun-Ichi; Suzuki, Masahiro; Iguchi, Mitsutaka; Yagi, Tetsuya; Arakawa, Yoshichika; Kimura, Kouji.

Antimicrob Agents Chemother ; 68(4): e0117923, 2024 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-38415648

19.

A multi-species outbreak of VIM-producing carbapenem-resistant bacteria in a burn unit and subsequent investigation of rapid development of cefiderocol resistance.

Freiberg, Jeffrey A; Tao, Lili; Manuel, Carmila; Mike, Laura A; Nelson, George E; Harris, Bryan D; Mathers, Amy J; Talbot, Thomas R; Skaar, Eric P; Humphries, Romney M.

Antimicrob Agents Chemother ; 68(4): e0150723, 2024 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-38376188

20.

I n vitro pharmacokinetics/pharmacodynamics of the ß-lactamase inhibitor, durlobactam, in combination with sulbactam against Acinetobacter baumannii-calcoaceticus complex.

O'Donnell, John; Tanudra, Angela; Chen, April; Miller, Alita A; McLeod, Sarah M; Tommasi, Rubén.

Antimicrob Agents Chemother ; 68(1): e0031223, 2024 Jan 10.

Artigo em Inglês | MEDLINE | ID: mdl-38092676

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Instituto Evandro Chagas

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